- Hume Care Plus takes first place. It is the only platform here that measures whether the weight you lose is fat or muscle, with a weekly 3D body scan, glycine, B12 and B6 in the protocol, and a licensed US clinician on your team.
- AbundRX is second, and still the lowest all-in number we have reviewed: $99 a month for semaglutide-based care, $149 for tirzepatide.
- TrimRx, DocSearch and Wellorithm are off this list. Our partnerships with all three ended or stopped working this month, and we explain exactly what that means.
- RetaClinic is off for a safety reason: its offer page now leads with retatrutide, a compound still in trials and not approved in any form.
- Two things still beat every price here: Medicare Part D at $50 a month, and the manufacturer's savings card on some commercial plans.
In September, the top spot on this list went to the cheapest price that did not move. This month it goes to something else: the program that does the most for you after the medication arrives.
Same three questions as every month. What do you actually pay at the dose that works, not the starter dose. What is around the molecule while you are on it. And can you reach a human at eleven at night when the side effects show up. In September, the first question decided the top spot. This month we are giving more weight to the second one, and the reason is simple: a serious share of the weight people lose on this kind of medication is muscle, not fat, and lost muscle is the main reason the weight comes back the moment they stop.
Why the top spot changed
Almost nobody quits a GLP-1 program in month one. Month one is the number from the advertisement, and it is usually true. People quit in month four, when the dose finally reaches the level that does something and the invoice climbs the ladder alongside it. That failure mode is still the first thing this ranking is built to catch, and every platform in the top six holds its price as your dose goes up.
Once the price holds, the next question decides the order. A platform that hands you a prescription and disappears has no way of knowing that you are losing muscle along with the fat, and no incentive to find out. A program that measures it, and adjusts your dose to your own data, is a different product from a prescription in a cold box.
A program that takes weight off you and a program that keeps it off are not the same product, and they are rarely the same price.
The criteria video, from when we first stopped ranking on the headline price.
Every platform below has a full written breakdown on this site: the prices we checked, the fine print we read, and what each one gets wrong. Where a link is an affiliate link, it is marked as one. Nine platforms made the cut this month.
1. Hume Care Plus: the only one that measures what you are losing
Most programs prescribe a medication and leave you alone with a bathroom scale that cannot tell fat from muscle. Hume builds a protocol around the medication. Glycine, vitamin B12 and vitamin B6 are in the plan from the start, to protect lean muscle and ease side effects. You get a weekly 3D body scan that tracks fat and muscle separately, so you see what is actually leaving your body instead of guessing from one number. A licensed US clinician is on your team with video visits, your dose is calibrated to your own data rather than a fixed schedule, and the app holds your daily plan, your medication log and your food log in one place. Delivery is free and next-day, and you can cancel the subscription at any time.
What you will find through our link right now is their physician-guided oral protocol: nothing to inject at any point, which for a lot of people is the difference between starting and never starting. In September we ranked the injectable version and the oral version as two separate entries; this month the offer page leads with the oral protocol, so Hume is one entry. Our HumeCare+ Oral review covers the needle-free side in detail.
The introductory offer starts from $7 a day, a little over $200 a month. That is not the cheapest number on this list, and we are not going to pretend it is: number two is half of that. What you pay for the difference is everything above, and it is the part that decides whether the weight stays off.
And because first place is held to the same standard as everyone else: the headline results on their page come from an internal analysis of their own members, not an independent trial, and results vary from one person to the next. The offer page now advertises a 180-day money-back promise. In September, the terms we read behind their guarantee were much narrower than the headline — a shorter window, first-time GLP-1 users only, every weekly weigh-in completed — so read the current terms yourself before you count on that refund. On Trustpilot they sit at 4.7 out of 5 across nearly three thousand reviews. If you want the most medical follow-up available in this market, this is the one to beat.
2. AbundRX: the cheapest all-in price we have reviewed
$99 a month for semaglutide-based care. $149 for tirzepatide-based care. When we reviewed it, the medication was inside that number, along with the provider review, the care planning and the follow-up, instead of arriving later as a second bill from a pharmacy. For context, the cash-pay average in this country runs around $347 a month. LegitScript certified, named providers, free fast shipping.
So why second rather than first. It is a newer platform with no long public track record yet, and that $99 rate is an introductory price, not a promise for life. If the lowest number is the only thing you are optimizing, start here anyway, knowing that you are buying a newer platform and an introductory rate.
3. bmiMD: the commitment is where the value is
Compounded tirzepatide, a dual GLP-1 and GIP medication, at the same price at every dose. The provider visit is included, you can message your provider about side effects and dosing, clinician access is around the clock and fully online, refills are automatic, and shipping is free on every subscription order. It is available in all fifty states, and if you turn out not to be eligible, you are refunded in full.
The price is where you need to pay attention. One month on its own is $349. The three-month plan brings it down to $159 a month. That gap is the whole story with bmiMD: the single month is expensive, and the value sits in the commitment. It is third because it is still a young platform, the rating you see is the one on its own page, and the good price depends on paying up front.
4. MEDVi: the biggest name on the list
More than 500,000 patients. Right now there is a fall sale: start for $99, no insurance needed, with fast free shipping. No membership and no hidden fees, free dietitian visits and care coaching included, and it is HSA and FSA approved. Injections start at $99, a once-a-day dissolvable tablet starts at $249, and they also prescribe brand-name GLP-1 medications, including a pill.
Two things keep it at four. Their compounded GLP-1s are dispensed by state-licensed pharmacies but they are not FDA-approved, and that whole channel has been under regulatory pressure. That is true of most of this list, and we would rather say it next to the biggest platform on it than bury it. And $99 is a starting price on a sale: your real monthly number shows up after the free intake, so read it carefully before you agree to anything.
5. ShedRx: the guarantee most of its competitors will not say out loud
Compounded injections from $199 a month, and liquid drops from $299 if needles are what has been stopping you. More than 150,000 members, health coaching included, HSA and FSA approved, and right now 10% off your first month of medication. Shed also puts a money-back guarantee on the table: lose 5% of your body weight in 120 days, or get your money back. Read the terms, but it is a guarantee most of its competitors will not say out loud.
What keeps it at five is depth. No body scans, no clinician in your pocket at midnight, and at $199 you are paying close to the price of number one for a lot less follow-up. It is a well-run, honest program. It just is not the deepest one here.
6. Aspen Health: flat at every dose, and one decision worth $1,340
The price holds from your first dose to your last: your provider steps your dose up, and nothing happens to your card. A licensed physician chooses semaglutide or tirzepatide from your intake instead of you picking a molecule by budget, and expedited shipping is included. On the plan grid we checked, it was $199 for the first month and $299 after that.
And here is the catch that matters more than titration. A year paid month by month came to $3,488, while the prepaid year was $2,148. Same treatment, thirteen hundred and forty dollars apart. If you are going to stay with Aspen for a year, that one decision saves you more than any coupon will, so check the current grid before you pay.
7. Oak: the lowest advertised entry price, still without a grid
One clinic for GLP-1, sexual health, NAD, longevity, hair and skin, with licensed US providers. The weight-loss line has been advertised from $89 a month, the lowest entry figure anywhere in this ranking, and this month their page adds promises worth noting: the same price at every dose, no membership fee, the doctor consult included, free shipping, and you are not charged until a provider approves you.
So why seventh. Same reason as in September. $89 is a from-price, there is still no price grid on the page, and you answer twelve questions before you see your number. The low figure belongs to the long plans. Take the quiz, and read the price you are quoted for a single month before you agree to anything.
8. Sesame Care: brand-name options and same-day pickup
Sesame is here for something broader than a weight-loss program. Care starts at $59 a month, with the medication billed separately, from $149 a month. That $59 is based on a twelve-month commitment, so it is not a month-to-month price. What Sesame does that nobody else here does: it gives you access to brand-name GLP-1 options, including the Wegovy pill from $149, and if you are prescribed, you can pick it up the same day at your local pharmacy instead of waiting for a box. You work with one dedicated provider over video, with messaging and weight tracking in the app, and Sesame holds 4.6 out of 5 on Trustpilot.
It is eighth because care and medication are two separate bills, and on the brand-name side the medication bill climbs quickly as your dose goes up.
9. Gala: one price, forever
A promise that ought to be boring and is not. The same flat price at every dose, no monthly membership, no hidden fees, cancel at any time, and a full refund if their medical provider disqualifies you. Unlimited provider visits, nutrition and mental health coaching, a one-on-one dietitian, and free two-day shipping. Right now their page runs a pre-Black Friday promotion advertising $250 off every month. When we went through this market looking specifically for hidden costs, Gala was one of only two platforms with genuinely complete pricing transparency.
Ninth, because the complaint that keeps coming back is response time at busy periods, and an independent comparison scores it 7.2 out of 10. Right choice if your priority is no surprises. Wrong choice if your priority is speed.
Why TrimRx, DocSearch and Wellorithm are off this list
Our number one in September is missing, and so are two other names. Nothing we know about the TrimRx, DocSearch or Wellorithm programs changed this month, and if you are already with one of them, nothing here is a reason to leave.
What changed is on our side. This site and the channel behind it are funded by the links on them, and our partnerships with all three ended or stopped working properly in November. We would rather take a name off the list than send you through a link that does not lead where it should. Their reviews stay up, dated, so you can still read what we found.
Why RetaClinic is off, and why it is a safety call
RetaClinic entered this ranking at tenth in September, and we liked its tirzepatide paired with glycine. This month its offer page leads with retatrutide, a triple-receptor compound (GLP-1, GIP and glucagon) that is still being tested in trials. It is not approved as a medication in any form, so nobody can sell you a version of it that has been through that process, however good the lab certificate looks. We are not ranking a platform whose headline product is that.
One more thing worth knowing: RetaClinic's page says it is part of Oak Longevity, the company behind Oak at number seven. Oak's weight-loss line is a compounded GLP-1 plus GIP, not retatrutide. Our September review of RetaClinic stays up, dated, with a note on top.
The platform we review, score, and deliberately leave out
Brand-name medication, the smoothest onboarding in telehealth, the best app in the category, and a provider you can message. About $353 a month in cash once the intro membership expires, with no body composition tracking and nothing in the protocol protecting the muscle you lose along with the fat.
If your commercial insurance or Medicare covers GLP-1, none of that arithmetic matters and Hims and Hers may well be your best option. If you are paying cash for a year, you are paying roughly seventeen hundred dollars more than an all-in program, for less of a program. That is why it is scored and reviewed but not ranked.
What these platforms do beyond weight loss
Aspen runs an NAD+ program from $149 a month, delivered as a small injection twice a week rather than as capsules: if you have taken NAD capsules and felt nothing, the delivery was the problem, not the compound. For sexual wellness, the tablets start at $49 a month, while the troche version runs up to $209 for the same category. Take the tablets.
Shed covers men's health, women's health, hair and skin from the same account as its weight-loss program, and Sesame's cash-price model reaches dermatology and women's health as well.
Two things that beat every price in this ranking
Before you pay cash anywhere, check these two first, because both undercut every number above.
Since July 1, Medicare Part D covers GLP-1 medication at $50 a month. If you have Medicare, or somebody in your family does, start there. And if you have commercial insurance, check whether the manufacturer's savings card works on your plan, because some people are paying between $0 and $25 a month. No cash program on this list competes with either of those. Our guide to GLP-1 insurance coverage walks through both routes, including what to do when the first claim gets denied.
The nine, side by side
| # | Platform | Entry price | What you're really paying for | The catch |
|---|---|---|---|---|
| 1 | Hume Care Plus | From $7/day intro | Weekly fat-vs-muscle scans, glycine + B12 + B6, US clinician, oral protocol | Results are company data; read the refund terms |
| 2 | AbundRX | $99/mo | The lowest all-in price, tirzepatide at $149 | New platform; the $99 rate is introductory |
| 3 | bmiMD | $159/mo on 3 months | Tirzepatide at the same price at every dose, 24/7 clinician access | $349 for a single month |
| 4 | MEDVi | From $99 (fall sale) | Dietitian visits, coaching, compounded and brand-name options | Real monthly price shown only after intake |
| 5 | ShedRx | $199/mo | Coaching, needle-free drops, 5% in 120 days guarantee | No body scans, no round-the-clock clinician |
| 6 | Aspen Health | $199 first month | Flat at every dose, physician picks the molecule | $1,340 gap between paying monthly and prepaying the year |
| 7 | Oak | From $89/mo | GLP-1, sexual health, NAD, longevity, hair and skin in one clinic | From-price with no published grid |
| 8 | Sesame Care | $59/mo care + medication | Brand-name options, same-day local pickup | Two bills; brand-name prices climb with the dose |
| 9 | Gala | Flat, quoted up front | One price at every dose, unlimited visits, dietitian | Support can be slow at peak times |
| — | Hims & Hers | $353/mo cash | Brand-name medication, the best app in the category | Reviewed but not ranked: no muscle protection, cash price too high |
Prices observed on the platforms' offer pages in November 2026, except where a section says "the grid we checked", which refers to our September review. Offers in this market change weekly, so see our price tracker. All prices in USD.
Ranked on customer reviews alone, the order changes
Value is one way to sort this market. Reputation is another, and we ran it as a separate exercise: three weeks going through every telehealth weight-loss platform we could find, cross-referencing our own data against Trustpilot, Google reviews, Reddit and the forums, and weeding out the fake reviews that would have skewed the result. Three glowing reviews prove nothing. A hundred consistent ones is where the evidence starts to hold, and where the fakes become easy to spot.
This list answers a different question from the one above. The value ranking asks what you get for what you pay. This one asks how many real customers are satisfied, and how consistently.
1. Wellorithm: the strongest, best-verified reputation
4.3 out of 5 on Trustpilot, labelled Excellent, plus an independent score of 8.3 out of 10 for clinical transparency and medical oversight. The reviews keep coming back to the same two things: the quality of the medical follow-up and how quickly support answers. The one recurring downside is the price after month one. Read our Wellorithm review.
2. Sesame Care: thousands of reviews, consistently strong
4.6 out of 5 on Trustpilot today. Patients are very positive about how fast they get an appointment and about the quality of the providers, tempered slightly by isolated billing complaints that do not change the overall trend.
3. TrimRx: a modest score, confirmed legitimate
Between 3 and 3.3 out of 5 on Trustpilot, but the fundamentals check out: accredited by the Better Business Bureau, certified by LegitScript, and billing only starts after clinical approval. The main complaint is prepaid packages people found hard to cancel. Read our TrimRx review.
4. Gala: decent, but mixed
Rated 7.2 out of 10 by an independent comparison. Competitive pricing and a concierge-style service, offset by reports of customer service that can be slow to respond.
Review scores move over time, so treat these as a snapshot of the evidence rather than a permanent verdict, and read the most recent reviews yourself before you commit. Every platform here prescribes real medication after a real eligibility assessment: not everyone qualifies, a licensed provider can decline you, and compounded medications are prepared by licensed pharmacies but are not FDA-approved finished products.
What changed since the September ranking
For the record, here is the September countdown. Hume Care Plus moves from second to first and absorbs the oral protocol that sat fifth. AbundRX, bmiMD, MEDVi, ShedRx, Aspen Health, Oak, Sesame Care and Gala keep their order and close up the gaps. TrimRx, DocSearch, Wellorithm and RetaClinic leave the list, for the reasons explained above.
The September 2026 ranking, kept here for reference. Its order is no longer current.
Questions people ask about this ranking
So where should you actually start?
If you can only carry one idea out of this article, make it this one: the thing you are buying is not the molecule, it is everything around the molecule, and the price you were shown has to survive your third dose.
- One price at every dose, consultation included
- Body composition tracked, not just scale weight
- A clinician you can reach when side effects hit
- A guarantee whose terms match the headline
- A prescription in a cold box and nothing else
- Starting-dose pricing that climbs as you titrate up
- A from-price with no published grid behind it
- Muscle lost with the fat, and regained as fat later
If you want the most follow-up this market offers, a weekly look at what you are actually losing and nothing to inject, Hume Care Plus is the one. If the smallest number is the only thing that matters, AbundRX at $99. If you want tirzepatide at one price for every dose and you are ready to commit for three months, bmiMD. And if you want brand-name medication you can pick up today, Sesame Care.
Check Medicare and your commercial plan first. If neither route works for you, start at the top of this list rather than the bottom of a price comparison. The difference between the two is usually a year of your life and the cost of doing it all again.
Medical disclaimer: this article compares services, prices and program structures. It is not medical advice. GLP-1 medication is prescription treatment, not everybody qualifies, a licensed provider can decline you, results vary, and compounded medication is prepared by licensed pharmacies but is not an FDA-approved finished product. Talk to a clinician before you start or stop anything.